Bupropion sustained release: a therapeutic overview.

Journal Article (Journal Article;Review)

Sustained-release bupropion (bupropion SR) represents a new form of an already known effective antidepressant drug. Its pharmacokinetics, mechanism of action, metabolism, and efficacy are reviewed. Benefit relative to placebo has been demonstrated in two large multicenter trials, with low doses (100 or 150 mg) having been shown to have therapeutic efficacy. An overview of all placebo-controlled trials of bupropion SR is given, and the differential properties of bupropion and serotonergic drugs are described. The concept of a catecholamine-indolamine spectrum is presented, along with its implications for possible differential therapeutics of selective antidepressants.

Full Text

Duke Authors

Cited Authors

  • Davidson, JR; Connor, KM

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 59 Suppl 4 /

Start / End Page

  • 25 - 31

PubMed ID

  • 9554318

International Standard Serial Number (ISSN)

  • 0160-6689


  • eng

Conference Location

  • United States