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Response characteristics to antidepressants and placebo in post-traumatic stress disorder.

Publication ,  Journal Article
Davidson, JR; Malik, ML; Sutherland, SN
Published in: Int Clin Psychopharmacol
November 1997

Characteristic response patterns are described for two antidepressant drugs and placebo in post-traumatic stress disorder. Early onset and steady improvement occurred on a global rating scale for both drugs and placebo in those who ultimately met responder criteria at the end of treatment. In certain cases, the magnitude of global response was greater for drug than for placebo. At weeks 2 or 4, the Clinical Global Impressions score for fluoxetine but not for amitriptyline, served as a good predictor of eventual response. In a review of numerous completed placebo-controlled trials, antidepressants were superior to placebo in seven out of eight comparisons using the Clinical Global Impressions, although specific effects on post-traumatic stress disorder scales were more variable. Drug response rates are similar for combat and civilian trauma samples, but placebo response rates may be higher in the latter. Effect sizes suggested a moderate-to-good effect for drug therapy.

Duke Scholars

Published In

Int Clin Psychopharmacol

DOI

ISSN

0268-1315

Publication Date

November 1997

Volume

12

Issue

6

Start / End Page

291 / 296

Location

England

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Placebos
  • Placebo Effect
  • Humans
  • Fluoxetine
  • Clinical Trials as Topic
  • Antidepressive Agents
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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ICMJE
MLA
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Davidson, J. R., Malik, M. L., & Sutherland, S. N. (1997). Response characteristics to antidepressants and placebo in post-traumatic stress disorder. Int Clin Psychopharmacol, 12(6), 291–296. https://doi.org/10.1097/00004850-199711000-00001
Davidson, J. R., M. L. Malik, and S. N. Sutherland. “Response characteristics to antidepressants and placebo in post-traumatic stress disorder.Int Clin Psychopharmacol 12, no. 6 (November 1997): 291–96. https://doi.org/10.1097/00004850-199711000-00001.
Davidson JR, Malik ML, Sutherland SN. Response characteristics to antidepressants and placebo in post-traumatic stress disorder. Int Clin Psychopharmacol. 1997 Nov;12(6):291–6.
Davidson, J. R., et al. “Response characteristics to antidepressants and placebo in post-traumatic stress disorder.Int Clin Psychopharmacol, vol. 12, no. 6, Nov. 1997, pp. 291–96. Pubmed, doi:10.1097/00004850-199711000-00001.
Davidson JR, Malik ML, Sutherland SN. Response characteristics to antidepressants and placebo in post-traumatic stress disorder. Int Clin Psychopharmacol. 1997 Nov;12(6):291–296.

Published In

Int Clin Psychopharmacol

DOI

ISSN

0268-1315

Publication Date

November 1997

Volume

12

Issue

6

Start / End Page

291 / 296

Location

England

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Placebos
  • Placebo Effect
  • Humans
  • Fluoxetine
  • Clinical Trials as Topic
  • Antidepressive Agents
  • 5202 Biological psychology
  • 3214 Pharmacology and pharmaceutical sciences