Panobinostat for the management of multiple myeloma.

Journal Article (Journal Article;Review)

Multiple myeloma (MM) is the second most common blood cancer following non-Hodgkin's lymphoma. While the treatments for MM have improved over the past decade, for the most part, it remains an incurable disease. For this reason newer therapeutic agents are needed to combat this malignancy. Panobinostat is a pan-deacetylase inhibitor that impedes protein destruction by disturbing the enzymatic activity of deacetylases. It was US FDA approved in February 2015 for the management of relapsed/refractory MM in combination with bortezomib and dexamethasone. Several trials are ongoing, exploring the utility of panobinostat in various other settings for the management of MM. This review will detail the biology, clinical efficacy and potential future applications of panobinostat in the treatment of MM.

Full Text

Duke Authors

Cited Authors

  • Sivaraj, D; Green, MM; Gasparetto, C

Published Date

  • March 2017

Published In

Volume / Issue

  • 13 / 6

Start / End Page

  • 477 - 488

PubMed ID

  • 27776419

Electronic International Standard Serial Number (EISSN)

  • 1744-8301

Digital Object Identifier (DOI)

  • 10.2217/fon-2016-0329


  • eng

Conference Location

  • England