Transcriptional regulation of matrix gla protein.

Journal Article (Journal Article)

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.

Full Text

Duke Authors

Cited Authors

  • Farzaneh-Far, A; Weissberg, PL; Proudfoot, D; Shanahan, CM

Published Date

  • 2001

Published In

Volume / Issue

  • 90 Suppl 3 /

Start / End Page

  • 38 - 42

PubMed ID

  • 11374031

International Standard Serial Number (ISSN)

  • 0300-5860

Digital Object Identifier (DOI)

  • 10.1007/s003920170040

Language

  • eng

Conference Location

  • Germany