Genetic influences on cerebral outcome after cardiac surgery.


Journal Article (Review)

Just as the influence of genetic variation on patient outcomes is being discussed in many other areas of medicine, so too are its effects on cerebral outcome after cardiac surgery now being described. Whereas early studies focused on neurocognitive outcome, where the single nucleotide polymorphisms of APOE4 and PL(A2) were the first investigated genetic targets, stroke is now being elaborated on with related single and multi-gene single nucleotide polymorphisms having been identified. Our work has established key links between post-cardiac surgery stroke and C-reactive protein (3'UTR 1846C/T) and interleukin-6 (-174 G/C) single nucleotide polymorphisms.

Full Text

Duke Authors

Cited Authors

  • Grocott, HP

Published Date

  • December 2006

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 291 - 296

PubMed ID

  • 17200087

Pubmed Central ID

  • 17200087

International Standard Serial Number (ISSN)

  • 1089-2532

Digital Object Identifier (DOI)

  • 10.1177/1089253206294344


  • eng

Conference Location

  • United States