Effects of acetaminophen and nonsteroidal anti-inflammatory drugs on progesterone production by porcine granulosa cells in vitro.


Journal Article

We investigated the effects of a group of pharmaceutical agents commonly ingested by reproductive-aged women, acetaminophen and the nonsteroidal anti-inflammatory drugs (NSAID), on progesterone (P) production by cultures of highly differentiated porcine granulosa cells. These compounds were added to cultures over a dose range of 10(-8) to 10(-5) M and P, and cell protein was measured after 24 hours. P production was suppressed by acetaminophen, fenoprofen, and sulindac to a maximum of 81%, 76%, and 71% of control, respectively. P production was enhanced by butazolidin at all doses tested to a maximum of 140% of control. Granulosa cell protein was suppressed by butazolidin and salicylic acid to a maximum of 81% of controls. These data imply that acetaminophen and several NSAID have the potential for clinical reproductive toxicity with differing individual effects on reproductive tract tissues, suggesting further selective testing in vivo.

Full Text

Duke Authors

Cited Authors

  • Haney, AF; Hughes, SF; Hughes, CL

Published Date

  • 1987

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 285 - 291

PubMed ID

  • 2980394

Pubmed Central ID

  • 2980394

International Standard Serial Number (ISSN)

  • 0890-6238

Digital Object Identifier (DOI)

  • 10.1016/0890-6238(87)90020-7


  • eng

Conference Location

  • United States