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The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina.

Publication ,  Journal Article
Novack, RL; Stefånsson, E; Hatchell, DL
Published in: Exp Eye Res
March 1990

Panretinal photocoagulation has been shown to raise preretinal oxygen tension in cats and monkeys breathing 100% oxygen. However, in normoxia, there is no significant difference between normal and photocoagulated areas. This is thought to be due to autoregulatory vasoconstriction of the retinal circulation. In avascular rabbit retina, photocoagulation effects on retinal oxygenation can be studied without the influence of retinal vascular autoregulation. We measured normoxic preretinal oxygen tension of normal and photocoagulated rabbit retina at 1, 7, 14 and 28 days after photocoagulation using polarographic oxygen electrodes. For all time points, preretinal oxygen tension of photocoagulated retina (42 +/- 14 torr; mean +/- S.D.) was higher than untreated retina (14 +/- 10 torr; mean +/- S.D., P less than 0.001). Light and electron microscopy of lasered retina showed that the improved oxygenation corresponded to loss of mitochondria-rich inner segments of the photoreceptors.

Duke Scholars

Published In

Exp Eye Res

DOI

ISSN

0014-4835

Publication Date

March 1990

Volume

50

Issue

3

Start / End Page

289 / 296

Location

England

Related Subject Headings

  • Retina
  • Rabbits
  • Oxygen Consumption
  • Ophthalmology & Optometry
  • Microscopy, Electron
  • Male
  • Light Coagulation
  • Female
  • Animals
  • 3212 Ophthalmology and optometry
 

Citation

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Novack, R. L., Stefånsson, E., & Hatchell, D. L. (1990). The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina. Exp Eye Res, 50(3), 289–296. https://doi.org/10.1016/0014-4835(90)90213-e
Novack, R. L., E. Stefånsson, and D. L. Hatchell. “The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina.Exp Eye Res 50, no. 3 (March 1990): 289–96. https://doi.org/10.1016/0014-4835(90)90213-e.
Novack RL, Stefånsson E, Hatchell DL. The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina. Exp Eye Res. 1990 Mar;50(3):289–96.
Novack, R. L., et al. “The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina.Exp Eye Res, vol. 50, no. 3, Mar. 1990, pp. 289–96. Pubmed, doi:10.1016/0014-4835(90)90213-e.
Novack RL, Stefånsson E, Hatchell DL. The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina. Exp Eye Res. 1990 Mar;50(3):289–296.
Journal cover image

Published In

Exp Eye Res

DOI

ISSN

0014-4835

Publication Date

March 1990

Volume

50

Issue

3

Start / End Page

289 / 296

Location

England

Related Subject Headings

  • Retina
  • Rabbits
  • Oxygen Consumption
  • Ophthalmology & Optometry
  • Microscopy, Electron
  • Male
  • Light Coagulation
  • Female
  • Animals
  • 3212 Ophthalmology and optometry