The effect of photocoagulation on the oxygenation and ultrastructure of avascular retina.
Published
Journal Article
Panretinal photocoagulation has been shown to raise preretinal oxygen tension in cats and monkeys breathing 100% oxygen. However, in normoxia, there is no significant difference between normal and photocoagulated areas. This is thought to be due to autoregulatory vasoconstriction of the retinal circulation. In avascular rabbit retina, photocoagulation effects on retinal oxygenation can be studied without the influence of retinal vascular autoregulation. We measured normoxic preretinal oxygen tension of normal and photocoagulated rabbit retina at 1, 7, 14 and 28 days after photocoagulation using polarographic oxygen electrodes. For all time points, preretinal oxygen tension of photocoagulated retina (42 +/- 14 torr; mean +/- S.D.) was higher than untreated retina (14 +/- 10 torr; mean +/- S.D., P less than 0.001). Light and electron microscopy of lasered retina showed that the improved oxygenation corresponded to loss of mitochondria-rich inner segments of the photoreceptors.
Full Text
Duke Authors
Cited Authors
- Novack, RL; Stefånsson, E; Hatchell, DL
Published Date
- March 1990
Published In
Volume / Issue
- 50 / 3
Start / End Page
- 289 - 296
PubMed ID
- 2318273
Pubmed Central ID
- 2318273
International Standard Serial Number (ISSN)
- 0014-4835
Digital Object Identifier (DOI)
- 10.1016/0014-4835(90)90213-e
Language
- eng
Conference Location
- England