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Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Publication ,  Journal Article
Jun, GR; Chung, J; Mez, J; Barber, R; Beecham, GW; Bennett, DA; Buxbaum, JD; Byrd, GS; Carrasquillo, MM; Crane, PK; Cruchaga, C; De Jager, P ...
Published in: Alzheimers Dement
July 2017

INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. RESULTS: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10-6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10-6). DISCUSSION: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

July 2017

Volume

13

Issue

7

Start / End Page

727 / 738

Location

United States

Related Subject Headings

  • Receptors, GABA
  • Polymorphism, Single Nucleotide
  • Peroxisomal Bifunctional Enzyme
  • NFI Transcription Factors
  • Molecular Chaperones
  • Membrane Glycoproteins
  • Humans
  • Heparin-binding EGF-like Growth Factor
  • Geriatrics
  • Genome-Wide Association Study
 

Citation

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Jun, G. R., Chung, J., Mez, J., Barber, R., Beecham, G. W., Bennett, D. A., … Farrer, L. A. (2017). Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement, 13(7), 727–738. https://doi.org/10.1016/j.jalz.2016.12.012
Jun, Gyungah R., Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W. Beecham, David A. Bennett, Joseph D. Buxbaum, et al. “Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Alzheimers Dement 13, no. 7 (July 2017): 727–38. https://doi.org/10.1016/j.jalz.2016.12.012.
Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul;13(7):727–38.
Jun, Gyungah R., et al. “Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Alzheimers Dement, vol. 13, no. 7, July 2017, pp. 727–38. Pubmed, doi:10.1016/j.jalz.2016.12.012.
Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang L-S, Wendlund JR, Winslow AR, Alzheimer’s Disease Genetics Consortium, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimers Dement. 2017 Jul;13(7):727–738.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

July 2017

Volume

13

Issue

7

Start / End Page

727 / 738

Location

United States

Related Subject Headings

  • Receptors, GABA
  • Polymorphism, Single Nucleotide
  • Peroxisomal Bifunctional Enzyme
  • NFI Transcription Factors
  • Molecular Chaperones
  • Membrane Glycoproteins
  • Humans
  • Heparin-binding EGF-like Growth Factor
  • Geriatrics
  • Genome-Wide Association Study