Coordinating expression of RNA binding proteins with their mRNA targets.

Journal Article (Journal Article)

Post-transcriptional regulation by RNA binding proteins (RBPs) plays prominent roles in a variety of biological processes. In this study, by analyzing the global regulatory relationship between RBPs and their target mRNAs in yeast, we discovered that most RBP genes are co-regulated with their target genes, but the RBPs tend to dampen expression variation among their target mRNAs. We further examined a well-studied RBP gene, PUF3, and found that the protein decreases the variation of its target mRNAs by differentially affecting their decay. We also constructed a mathematical model to explain the relationship between RBPs and the expression of their target genes. Our results provided new insights into the functional importance of RBPs in coordinating the expression of their target genes.

Full Text

Duke Authors

Cited Authors

  • Jiang, H; Xu, L; Wang, Z; Keene, J; Gu, Z

Published Date

  • November 24, 2014

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 7175 -

PubMed ID

  • 25417751

Pubmed Central ID

  • PMC4241525

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep07175


  • eng

Conference Location

  • England