Seroprevalence of human parvovirus B19 in healthy blood donors.

Published

Journal Article

BACKGROUND: Human parvovirus B19 is an emerging transfusion transmitted infection. Although parvovirus B19 infection is connected with severe complications in some recipients, donor screening is not yet mandatory. To reduce the risk of contamination, plasma-pool screening and exclusion of highly viraemic donations are recommended. In this study the prevalence of parvovirus B19 in healthy blood donors was detected by ELISA. METHODS: A total of 1633 samples were screened for IgM and IgG antibodies against parvovirus B19 by ELISA. The initial 540 samples were screened for both IgM and IgG class antibodies and remaining 1093 samples were screened for only IgM class antibodies by ELISA. RESULTS: Net prevalence of IgM antibodies to human parvovirus B19 in our study was 7.53% and prevalence of IgG antibodies was 27.96%. Dual positivity (IgG and IgM) was 2.40%. CONCLUSION: The seroprevalence of human parvovirus B19 among blood donor population in our study is high, and poses an adverse transfusion risk especially in high-risk group of patients who have no detectable antibodies to B19. Studies with large sample size are needed to validate these results.

Full Text

Duke Authors

Cited Authors

  • Kumar, S; Gupta, RM; Sen, S; Sarkar, RS; Philip, J; Kotwal, A; Sumathi, SH

Published Date

  • July 2013

Published In

Volume / Issue

  • 69 / 3

Start / End Page

  • 268 - 272

PubMed ID

  • 24600121

Pubmed Central ID

  • 24600121

Electronic International Standard Serial Number (EISSN)

  • 2213-4743

International Standard Serial Number (ISSN)

  • 0377-1237

Digital Object Identifier (DOI)

  • 10.1016/j.mjafi.2012.11.009

Language

  • eng