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Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.

Publication ,  Journal Article
Foo, JN; Chung, SJ; Tan, LC; Liany, H; Ryu, H-S; Hong, M; Koh, TH; Irwan, ID; Au, W-L; Prakash, K-M; Aung, T; Cheng, C-Y; Chong, S-A; Lee, J ...
Published in: Mov Disord
April 2016

BACKGROUND: Genome-wide association studies have identified several loci associated with Parkinson's disease (PD). Whole-exome sequencing detects rare coding variants, but their links with PD genome-wide association study loci are unknown. Our objective was to investigate whether nonsynonymous variants in LRRK2 can explain associations at the PD-associated locus tagged by rs1994090. METHODS: We sequenced all coding exons of LRRK2 in 453 East Asian samples and evaluated linkage disequilibrium between each nonsynonymous variant and rs1994090. We then tested selected variants and haplotypes for association with PD in 13,581 East Asian samples. RESULTS: Of all the nonsynonymous variants, only p.Gly2385Arg was in moderate linkage disequilibrium with rs1994090 and was observed on haplotypes tagged by the rs1994090-C risk allele. Conditional analyses showed that associations at these 2 variants are not independent. CONCLUSIONS: LRRK2 p.Gly2385Arg can explain most if not all of the PD association at rs1994090 in East Asians, but other nonsynonymous variants are independent. © 2015 International Parkinson and Movement Disorder Society.

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Published In

Mov Disord

DOI

EISSN

1531-8257

Publication Date

April 2016

Volume

31

Issue

4

Start / End Page

484 / 487

Location

United States

Related Subject Headings

  • Singapore
  • Republic of Korea
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Humans
  • Genome-Wide Association Study
  • Female
 

Citation

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Foo, J. N., Chung, S. J., Tan, L. C., Liany, H., Ryu, H.-S., Hong, M., … Tan, E.-K. (2016). Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease. Mov Disord, 31(4), 484–487. https://doi.org/10.1002/mds.26495
Foo, Jia Nee, Sun Ju Chung, Louis C. Tan, Herty Liany, Ho-Sung Ryu, Myunghee Hong, Tat Hung Koh, et al. “Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.Mov Disord 31, no. 4 (April 2016): 484–87. https://doi.org/10.1002/mds.26495.
Foo JN, Chung SJ, Tan LC, Liany H, Ryu H-S, Hong M, et al. Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease. Mov Disord. 2016 Apr;31(4):484–7.
Foo, Jia Nee, et al. “Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.Mov Disord, vol. 31, no. 4, Apr. 2016, pp. 484–87. Pubmed, doi:10.1002/mds.26495.
Foo JN, Chung SJ, Tan LC, Liany H, Ryu H-S, Hong M, Koh TH, Irwan ID, Au W-L, Prakash K-M, Aung T, Cheng C-Y, Chong S-A, Khor CC, Lee J, Tai E-S, Vithana EN, Wong T-Y, Song K, Liu J, Tan E-K. Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease. Mov Disord. 2016 Apr;31(4):484–487.
Journal cover image

Published In

Mov Disord

DOI

EISSN

1531-8257

Publication Date

April 2016

Volume

31

Issue

4

Start / End Page

484 / 487

Location

United States

Related Subject Headings

  • Singapore
  • Republic of Korea
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Humans
  • Genome-Wide Association Study
  • Female