Validation of four definitions of melancholia by the dexamethasone suppression test.

Journal Article (Journal Article)

The authors evaluated four sets of diagnostic criteria, the Newcastle Index, DSM-III, RDC, and the Michigan Diagnostic Index, for the diagnosis of melancholia. Forty-nine depressed inpatients, all of whom met RDC for major depression, also received consensus diagnostic assessment for melancholia. The dexamethasone suppression test (DST) was administered before drug treatment began. Results showed that the sensitivity of the DST ranged from 39% to 48%, specificity from 80% to 100%, and diagnostic confidence from 66% to 100%. All four scales received validation, but DSM-III showed the lowest specificity and predictive value.

Full Text

Duke Authors

Cited Authors

  • Davidson, J; Lipper, S; Zung, WW; Strickland, R; Krishnan, R; Mahorney, S

Published Date

  • October 1, 1984

Published In

Volume / Issue

  • 141 / 10

Start / End Page

  • 1220 - 1223

PubMed ID

  • 6486256

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.141.10.1220


  • eng

Conference Location

  • United States