Neurogenesis and depression.
Published
Journal Article
The recognition that the brain continues to generate new neurons well into adulthood has made a marked impact on the field of neuroscience in general and specifically on neurobiological models of the pathogenesis of major depression. Stress, neuroendocrine activation, neurotransmitter systems, and other factors can down-regulate the process of neurogenesis and may contribute to certain morphological changes seen in depression. Evidence is emerging that antidepressant treatments may mitigate these effects by stimulating neurogenesis in particular regions of the brain. This review introduces the reader to recent literature on neurogenesis as it relates to the understanding and treatment of depression.
Full Text
Duke Authors
Cited Authors
- Perera, TD; Lisanby, SH
Published Date
- November 2000
Published In
Volume / Issue
- 6 / 6
Start / End Page
- 322 - 333
PubMed ID
- 15990493
Pubmed Central ID
- 15990493
International Standard Serial Number (ISSN)
- 1527-4160
Digital Object Identifier (DOI)
- 10.1097/00131746-200011000-00003
Language
- eng
Conference Location
- United States