Regeneration of a transplanted liver after right hepatic lobectomy.

Journal Article (Journal Article)

Liver regeneration has been described after heterotopic liver transplantation, small-for-size orthotopic liver transplantation and reduced-size liver transplantation. In this report, we document the regenerative response of a whole liver transplant to major resection for the first time. A right hepatic lobectomy for liver ischemia was performed in a 30-year-old female after transplantation for autoimmune disease of the liver. Volumetric analysis of computed tomography (CT) scans revealed a preoperative liver volume of 1,961 mL, whereas analysis of the 6-week posthepatectomy CT scan showed a volume of 1,820 mL. Factors influencing regeneration in the setting of a liver transplant include rejection, ischemia/thrombosis, infection, or cyclosporine hepatotrophic/hepatotoxic effects. These factors, balanced with the intrinsic ability of hepatocytes to achieve a standard liver volume, determine the extent of regeneration.

Full Text

Duke Authors

Cited Authors

  • Chari, RS; Baker, ME; Sue, SR; Meyers, WC

Published Date

  • May 1996

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 233 - 234

PubMed ID

  • 9346653

International Standard Serial Number (ISSN)

  • 1074-3022

Digital Object Identifier (DOI)

  • 10.1002/lt.500020309


  • eng

Conference Location

  • United States