A model for biliary and vascular access in the unanesthetized, unrestrained rat.

Journal Article (Journal Article)

Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.

Full Text

Duke Authors

Cited Authors

  • Epstein, RE; Branum, GD; Cucchiaro, G; Meyers, WC

Published Date

  • October 1990

Published In

Volume / Issue

  • 48 / 4

Start / End Page

  • 539 - 542

PubMed ID

  • 2075205

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/0031-9384(90)90296-g


  • eng

Conference Location

  • United States