A model for biliary and vascular access in the unanesthetized, unrestrained rat.
Publication
, Journal Article
Epstein, RE; Branum, GD; Cucchiaro, G; Meyers, WC
Published in: Physiol Behav
October 1990
Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monitoring of biliary secretions in the intact, unrestrained, unanesthetized rat for extended periods of time is described. Sample experiments demonstrated a 20% complication rate and an 85% 24-hour survival. This model may prove useful in studies requiring chronic vascular and visceral catheterization in the awake rat.
Duke Scholars
Published In
Physiol Behav
DOI
ISSN
0031-9384
Publication Date
October 1990
Volume
48
Issue
4
Start / End Page
539 / 542
Location
United States
Related Subject Headings
- Restraint, Physical
- Rats, Inbred Strains
- Rats
- Models, Biological
- Male
- Catheterization
- Blood Vessels
- Biliary Tract
- Bile
- Behavioral Science & Comparative Psychology
Citation
APA
Chicago
ICMJE
MLA
NLM
Epstein, R. E., Branum, G. D., Cucchiaro, G., & Meyers, W. C. (1990). A model for biliary and vascular access in the unanesthetized, unrestrained rat. Physiol Behav, 48(4), 539–542. https://doi.org/10.1016/0031-9384(90)90296-g
Epstein, R. E., G. D. Branum, G. Cucchiaro, and W. C. Meyers. “A model for biliary and vascular access in the unanesthetized, unrestrained rat.” Physiol Behav 48, no. 4 (October 1990): 539–42. https://doi.org/10.1016/0031-9384(90)90296-g.
Epstein RE, Branum GD, Cucchiaro G, Meyers WC. A model for biliary and vascular access in the unanesthetized, unrestrained rat. Physiol Behav. 1990 Oct;48(4):539–42.
Epstein, R. E., et al. “A model for biliary and vascular access in the unanesthetized, unrestrained rat.” Physiol Behav, vol. 48, no. 4, Oct. 1990, pp. 539–42. Pubmed, doi:10.1016/0031-9384(90)90296-g.
Epstein RE, Branum GD, Cucchiaro G, Meyers WC. A model for biliary and vascular access in the unanesthetized, unrestrained rat. Physiol Behav. 1990 Oct;48(4):539–542.
Published In
Physiol Behav
DOI
ISSN
0031-9384
Publication Date
October 1990
Volume
48
Issue
4
Start / End Page
539 / 542
Location
United States
Related Subject Headings
- Restraint, Physical
- Rats, Inbred Strains
- Rats
- Models, Biological
- Male
- Catheterization
- Blood Vessels
- Biliary Tract
- Bile
- Behavioral Science & Comparative Psychology