Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women.

Published

Journal Article

Background: To our knowledge, no previous study has evaluated the associations of antioxidant intake with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease.Objective: We sought to evaluate these associations among 406 ovarian cancer cases and 632 age- and site-matched controls of African-American descent recruited from AACES (African American Cancer Epidemiology Study), a population-based, case-control study in 11 geographical areas within the United States.Methods: Multivariable logistic regression models were used to estimate ORs and 95% CIs adjusted for a wide range of potentially confounding factors, including age, region, education, parity, oral contraceptive use, menopause, tubal ligation, family history, body mass index (BMI), smoking status, total energy, and physical activity.Results: Women with the highest intakes of supplemental selenium (>20 μg/d) had an ∼30% lower risk of ovarian cancer than those with no supplemental intake (OR: 0.67; 95% CI: 0.46, 0.97; P-trend = 0.035). This inverse association was stronger in current smokers (OR: 0.13; 95% CI: 0.04, 0.46; P-trend = 0.001). There was no association with dietary selenium. The associations with carotenoid intakes were weak and nonsignificant (P = 0.07-0.60). We observed no association with dietary or supplemental intake of vitamin C or vitamin E. There were no appreciable differences in results between serous and nonserous tumors.Conclusions: These findings provide the first insights, to our knowledge, into the potential association between antioxidants and ovarian cancer in African-American women, indicating potential inverse associations with supplemental selenium.

Full Text

Duke Authors

Cited Authors

  • Terry, PD; Qin, B; Camacho, F; Moorman, PG; Alberg, AJ; Barnholtz-Sloan, JS; Bondy, M; Cote, ML; Funkhouser, E; Guertin, KA; Peters, ES; Schwartz, AG; Schildkraut, JM; Bandera, EV

Published Date

  • April 2017

Published In

Volume / Issue

  • 147 / 4

Start / End Page

  • 621 - 627

PubMed ID

  • 28202637

Pubmed Central ID

  • 28202637

Electronic International Standard Serial Number (EISSN)

  • 1541-6100

Digital Object Identifier (DOI)

  • 10.3945/jn.116.243279

Language

  • eng

Conference Location

  • United States