A molecular genetic linkage map of mouse chromosome 7.

Published

Journal Article

The homology between mouse chromosome 7 and human chromosomes 11, 15, and 19 was examined using interspecific backcross animals derived from mating C3H/HeJ-gld/gld and Mus spretus mice. In an earlier study, we reported on the linkage relationships of 16 loci on mouse chromosome 7 and the homologous relationship between this chromosome and the myotonic dystrophy gene region on human chromosome 19. Segregation analyses were used to extend the gene linkage relationships on mouse chromosome 7 by an additional 21 loci. Seven of these genes (Cyp2a, D19F11S1h, Myod-1, Otf-2, Rnu1p70, Rnu2pa, and Xrcc-1) were previously unmapped in the mouse. Several potential mouse chromosome 7 genes (Mel, Hkr-1, Icam-1, Pvs) did not segregate with chromosome 7 markers, and provisional chromosomal assignments were made. This study establishes a detailed molecular genetic linkage map of mouse chromosome 7 that will be useful as a framework for determining linkage relationships of additional molecular markers and for identifying homologous disease genes in mice and humans.

Full Text

Duke Authors

Cited Authors

  • Saunders, AM; Seldin, MF

Published Date

  • November 1990

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 525 - 535

PubMed ID

  • 1981054

Pubmed Central ID

  • 1981054

International Standard Serial Number (ISSN)

  • 0888-7543

Language

  • eng

Conference Location

  • United States