A molecular genetic linkage map of mouse chromosome 7.
Published
Journal Article
The homology between mouse chromosome 7 and human chromosomes 11, 15, and 19 was examined using interspecific backcross animals derived from mating C3H/HeJ-gld/gld and Mus spretus mice. In an earlier study, we reported on the linkage relationships of 16 loci on mouse chromosome 7 and the homologous relationship between this chromosome and the myotonic dystrophy gene region on human chromosome 19. Segregation analyses were used to extend the gene linkage relationships on mouse chromosome 7 by an additional 21 loci. Seven of these genes (Cyp2a, D19F11S1h, Myod-1, Otf-2, Rnu1p70, Rnu2pa, and Xrcc-1) were previously unmapped in the mouse. Several potential mouse chromosome 7 genes (Mel, Hkr-1, Icam-1, Pvs) did not segregate with chromosome 7 markers, and provisional chromosomal assignments were made. This study establishes a detailed molecular genetic linkage map of mouse chromosome 7 that will be useful as a framework for determining linkage relationships of additional molecular markers and for identifying homologous disease genes in mice and humans.
Full Text
Duke Authors
Cited Authors
- Saunders, AM; Seldin, MF
Published Date
- November 1990
Published In
Volume / Issue
- 8 / 3
Start / End Page
- 525 - 535
PubMed ID
- 1981054
Pubmed Central ID
- 1981054
International Standard Serial Number (ISSN)
- 0888-7543
Digital Object Identifier (DOI)
- 10.1016/0888-7543(90)90040-2
Language
- eng
Conference Location
- United States