Translating protein phosphatase research into treatments for neurodegenerative diseases.

Journal Article (Journal Article;Review)

Many of the major neurodegenerative disorders are characterized by the accumulation of intracellular protein aggregates in neurons and other cells in brain, suggesting that errors in protein quality control mechanisms associated with the aging process play a critical role in the onset and progression of disease. The increased understanding of the unfolded protein response (UPR) signaling network and, more specifically, the structure and function of eIF2α phosphatases has enabled the development or discovery of small molecule inhibitors that show great promise in restoring protein homeostasis and ameliorating neuronal damage and death. While this review focuses attention on one or more eIF2α phosphatases, the wide range of UPR proteins that are currently being explored as potential drug targets bodes well for the successful future development of therapies to preserve neuronal function and treat neurodegenerative disease.

Full Text

Duke Authors

Cited Authors

  • Sundaram, JR; Lee, ICJ; Shenolikar, S

Published Date

  • February 8, 2017

Published In

Volume / Issue

  • 45 / 1

Start / End Page

  • 101 - 112

PubMed ID

  • 28202663

Electronic International Standard Serial Number (EISSN)

  • 1470-8752

Digital Object Identifier (DOI)

  • 10.1042/BST20160157


  • eng

Conference Location

  • England