Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.

Journal Article (Journal Article)

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.

Full Text

Duke Authors

Cited Authors

  • Chandrawati, R; Chang, JYH; Reina-Torres, E; Jumeaux, C; Sherwood, JM; Stamer, WD; Zelikin, AN; Overby, DR; Stevens, MM

Published Date

  • April 2017

Published In

Volume / Issue

  • 29 / 16

PubMed ID

  • 28221702

Pubmed Central ID

  • PMC5400071

Electronic International Standard Serial Number (EISSN)

  • 1521-4095

Digital Object Identifier (DOI)

  • 10.1002/adma.201604932


  • eng

Conference Location

  • Germany