Stimulated Raman scattering spectroscopic optical coherence tomography.


Journal Article

We integrate spectroscopic optical coherence tomography (SOCT) with stimulated Raman scattering (SRS) to enable simultaneously multiplexed spatial and spectral imaging with sensitivity to many endogenous biochemical species that play an important role in biology and medicine. The combined approach, termed SRS-SOCT, overcomes the limitations of each individual method. Ultimately, SRS-SOCT has the potential to achieve fast, volumetric, and highly sensitive label-free molecular imaging. We demonstrate the approach by imaging excised human adipose tissue and detecting the lipids' Raman signatures in the high-wavenumber region.

Full Text

Duke Authors

Cited Authors

  • Robles, FE; Zhou, KC; Fischer, MC; Warren, WS

Published Date

  • February 14, 2017

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 243 - 246

PubMed ID

  • 29302608

Pubmed Central ID

  • 29302608

Electronic International Standard Serial Number (EISSN)

  • 2334-2536

International Standard Serial Number (ISSN)

  • 2334-2536

Digital Object Identifier (DOI)

  • 10.1364/OPTICA.4.000243


  • eng