Low- but Not High-Frequency LFP Correlates with Spontaneous BOLD Fluctuations in Rat Whisker Barrel Cortex.


Journal Article

Resting-state magnetic resonance imaging (rsMRI) is thought to reflect ongoing spontaneous brain activity. However, the precise neurophysiological basis of rsMRI signal remains elusive. Converging evidence supports the notion that local field potential (LFP) signal in the high-frequency range correlates with fMRI response evoked by a task (e.g., visual stimulation). It remains uncertain whether this relationship extends to rsMRI. In this study, we systematically modulated LFP signal in the whisker barrel cortex (WBC) by unilateral deflection of rat whiskers. Results show that functional connectivity between bilateral WBC was significantly modulated at the 2 Hz, but not at the 4 or 6 Hz, stimulus condition. Electrophysiologically, only in the low-frequency range (<5 Hz) was the LFP power synchrony in bilateral WBC significantly modulated at 2 Hz, but not at 4- or 6-Hz whisker stimulation, thus distinguishing these 2 experimental conditions, and paralleling the findings in rsMRI. LFP power synchrony in other frequency ranges was modulated in a way that was neither unique to the specific stimulus conditions nor parallel to the fMRI results. Our results support the hypothesis that emphasizes the role of low-frequency LFP signal underlying rsMRI.

Full Text

Cited Authors

  • Lu, H; Wang, L; Rea, WW; Brynildsen, JK; Jaime, S; Zuo, Y; Stein, EA; Yang, Y

Published Date

  • February 2016

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 683 - 694

PubMed ID

  • 25331598

Pubmed Central ID

  • 25331598

Electronic International Standard Serial Number (EISSN)

  • 1460-2199

International Standard Serial Number (ISSN)

  • 1047-3211

Digital Object Identifier (DOI)

  • 10.1093/cercor/bhu248


  • eng