New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Published online

Journal Article

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

Full Text

Duke Authors

Cited Authors

  • Lu, Y; Day, FR; Gustafsson, S; Buchkovich, ML; Na, J; Bataille, V; Cousminer, DL; Dastani, Z; Drong, AW; Esko, T; Evans, DM; Falchi, M; Feitosa, MF; Ferreira, T; Hedman, ÅK; Haring, R; Hysi, PG; Iles, MM; Justice, AE; Kanoni, S; Lagou, V; Li, R; Li, X; Locke, A; Lu, C; Mägi, R; Perry, JRB; Pers, TH; Qi, Q; Sanna, M; Schmidt, EM; Scott, WR; Shungin, D; Teumer, A; Vinkhuyzen, AAE; Walker, RW; Westra, H-J; Zhang, M; Zhang, W; Zhao, JH; Zhu, Z; Afzal, U; Ahluwalia, TS; Bakker, SJL; Bellis, C; Bonnefond, A; Borodulin, K; Buchman, AS; Cederholm, T; Choh, AC; Choi, HJ; Curran, JE; de Groot, LCPGM; De Jager, PL; Dhonukshe-Rutten, RAM; Enneman, AW; Eury, E; Evans, DS; Forsen, T; Friedrich, N; Fumeron, F; Garcia, ME; Gärtner, S; Han, B-G; Havulinna, AS; Hayward, C; Hernandez, D; Hillege, H; Ittermann, T; Kent, JW; Kolcic, I; Laatikainen, T; Lahti, J; Mateo Leach, I; Lee, CG; Lee, J-Y; Liu, T; Liu, Y; Lobbens, S; Loh, M; Lyytikäinen, L-P; Medina-Gomez, C; Michaëlsson, K; Nalls, MA; Nielson, CM; Oozageer, L; Pascoe, L; Paternoster, L; Polašek, O; Ripatti, S; Sarzynski, MA; Shin, CS; Narančić, NS; Spira, D; Srikanth, P; Steinhagen-Thiessen, E; Sung, YJ; Swart, KMA; Taittonen, L; Tanaka, T; Tikkanen, E; van der Velde, N; van Schoor, NM; Verweij, N; Wright, AF; Yu, L; Zmuda, JM; Eklund, N; Forrester, T; Grarup, N; Jackson, AU; Kristiansson, K; Kuulasmaa, T; Kuusisto, J; Lichtner, P; Luan, J; Mahajan, A; Männistö, S; Palmer, CD; Ried, JS; Scott, RA; Stancáková, A; Wagner, PJ; Demirkan, A; Döring, A; Gudnason, V; Kiel, DP; Kühnel, B; Mangino, M; Mcknight, B; Menni, C; O'Connell, JR; Oostra, BA; Shuldiner, AR; Song, K; Vandenput, L; van Duijn, CM; Vollenweider, P; White, CC; Boehnke, M; Boettcher, Y; Cooper, RS; Forouhi, NG; Gieger, C; Grallert, H; Hingorani, A; Jørgensen, T; Jousilahti, P; Kivimaki, M; Kumari, M; Laakso, M; Langenberg, C; Linneberg, A; Luke, A; Mckenzie, CA; Palotie, A; Pedersen, O; Peters, A; Strauch, K; Tayo, BO; Wareham, NJ; Bennett, DA; Bertram, L; Blangero, J; Blüher, M; Bouchard, C; Campbell, H; Cho, NH; Cummings, SR; Czerwinski, SA; Demuth, I; Eckardt, R; Eriksson, JG; Ferrucci, L; Franco, OH; Froguel, P; Gansevoort, RT; Hansen, T; Harris, TB; Hastie, N; Heliövaara, M; Hofman, A; Jordan, JM; Jula, A; Kähönen, M; Kajantie, E; Knekt, PB; Koskinen, S; Kovacs, P; Lehtimäki, T; Lind, L; Liu, Y; Orwoll, ES; Osmond, C; Perola, M; Pérusse, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Rivadeneira, F; Rudan, I; Salomaa, V; Sørensen, TIA; Stumvoll, M; Tönjes, A; Towne, B; Tranah, GJ; Tremblay, A; Uitterlinden, AG; van der Harst, P; Vartiainen, E; Viikari, JS; Vitart, V; Vohl, M-C; Völzke, H; Walker, M; Wallaschofski, H; Wild, S; Wilson, JF; Yengo, L; Bishop, DT; Borecki, IB; Chambers, JC; Cupples, LA; Dehghan, A; Deloukas, P; Fatemifar, G; Fox, C; Furey, TS; Franke, L; Han, J; Hunter, DJ; Karjalainen, J; Karpe, F; Kaplan, RC; Kooner, JS; McCarthy, MI; Murabito, JM; Morris, AP; Bishop, JAN; North, KE; Ohlsson, C; Ong, KK; Prokopenko, I; Richards, JB; Schadt, EE; Spector, TD; Widén, E; Willer, CJ; Yang, J; Ingelsson, E; Mohlke, KL; Hirschhorn, JN; Pospisilik, JA; Zillikens, MC; Lindgren, C; Kilpeläinen, TO; Loos, RJF

Published Date

  • February 1, 2016

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 10495 -

PubMed ID

  • 26833246

Pubmed Central ID

  • 26833246

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms10495

Language

  • eng

Conference Location

  • England