A genomic screen of autism: evidence for a multilocus etiology.
We have conducted a genome screen of autism, by linkage analysis in an initial set of 90 multiplex sibships, with parents, containing 97 independent affected sib pairs (ASPs), with follow-up in 49 additional multiplex sibships, containing 50 ASPs. In total, 519 markers were genotyped, including 362 for the initial screen, and an additional 157 were genotyped in the follow-up. As a control, we also included in the analysis unaffected sibs, which provided 51 discordant sib pairs (DSPs) for the initial screen and 29 for the follow-up. In the initial phase of the work, we observed increased identity by descent (IBD) in the ASPs (sharing of 51.6%) compared with the DSPs (sharing of 50.8%). The excess sharing in the ASPs could not be attributed to the effect of a small number of loci but, rather, was due to the modest increase in the entire distribution of IBD. These results are most compatible with a model specifying a large number of loci (perhaps >/=15) and are less compatible with models specifying
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Related Subject Headings
- Statistical Distributions
- Sex Factors
- Nuclear Family
- Multifactorial Inheritance
- Molecular Sequence Data
- Models, Genetic
- Microsatellite Repeats
- Matched-Pair Analysis
- Male
- Linkage Disequilibrium
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Statistical Distributions
- Sex Factors
- Nuclear Family
- Multifactorial Inheritance
- Molecular Sequence Data
- Models, Genetic
- Microsatellite Repeats
- Matched-Pair Analysis
- Male
- Linkage Disequilibrium