Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy.

Published

Journal Article (Review)

Thyroid hormone (TH) actions on development and metabolism have been studied ever since the discovery of thyroxine almost a century ago. Initial studies focused on the physiological and biochemical actions of TH. Later, the cloning of the thyroid hormone receptor (THR) isoforms and the development of techniques enabled the study of TH regulation of complex cellular processes (such as gene transcription). Recently we found that TH activates secondary transcription factors such as FOXO1, to amplify gene transcription; and also is a potent inducer of autophagy that was critical for fatty acid β-oxidation in the liver. This review summarizes the recent advancements in our understanding of TH regulation of gene expression of metabolic genes (via co-regulators/transcription factors and epigenetic control) and autophagy in the liver. Our deeper understanding of TH action recently has led to the development of tissue- and THR isoform-specific TH mimetics that may be useful for the treatment of metabolic disorders.

Full Text

Duke Authors

Cited Authors

  • Singh, BK; Sinha, RA; Ohba, K; Yen, PM

Published Date

  • December 2017

Published In

Volume / Issue

  • 458 /

Start / End Page

  • 160 - 168

PubMed ID

  • 28216439

Pubmed Central ID

  • 28216439

Electronic International Standard Serial Number (EISSN)

  • 1872-8057

International Standard Serial Number (ISSN)

  • 0303-7207

Digital Object Identifier (DOI)

  • 10.1016/j.mce.2017.02.018

Language

  • eng