TGF-β Family Signaling in the Control of Cell Proliferation and Survival.

Published online

Journal Article (Review)

The transforming growth factor β (TGF-β) family controls many fundamental aspects of cellular behavior. With advances in the molecular details of the TGF-β signaling cascade and its cross talk with other signaling pathways, we now have a more coherent understanding of the cytostatic program induced by TGF-β. However, the molecular mechanisms are still largely elusive for other cellular processes that are regulated by TGF-β and determine a cell's proliferation and survival, apoptosis, dormancy, autophagy, and senescence. The difficulty in defining TGF-β's roles partly stems from the context-dependent nature of TGF-β signaling. Here, we review our current understanding and recent progress on the biological effects of TGF-β at the cellular level, with the hope of providing a framework for understanding how cells respond to TGF-β signals in specific contexts, and why disruption of such mechanisms may result in different human diseases including cancer.

Full Text

Duke Authors

Cited Authors

  • Zhang, Y; Alexander, PB; Wang, X-F

Published Date

  • April 3, 2017

Published In

Volume / Issue

  • 9 / 4

PubMed ID

  • 27920038

Pubmed Central ID

  • 27920038

Electronic International Standard Serial Number (EISSN)

  • 1943-0264

Digital Object Identifier (DOI)

  • 10.1101/cshperspect.a022145

Language

  • eng

Conference Location

  • United States