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Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis.

Publication ,  Journal Article
Yates, WR; Mitchell, J; John Rush, A; Trivedi, M; Wisniewski, SR; Warden, D; Bryan, C; Fava, M; Husain, MM; Gaynes, BN
Published in: Prim Care Companion J Clin Psychiatry
2007

BACKGROUND: Concurrent medical comorbidity influences the accurate diagnosis and treatment of major depressive disorder (MDD). OBJECTIVE: The objective of this study was to validate previous findings from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study using a confirmation analysis in a previously unanalyzed cohort. DESIGN: Baseline cross-sectional case-control study of patients enrolling in a prospective randomized multistage treatment study of nonpsychotic MDD. SETTING: Fourteen regional U.S. centers representing 18 primary care and 23 psychiatric practices. PARTICIPANTS: 2541 outpatients with DSM-IV nonpsychotic MDD. MEASUREMENTS: Sociodemographic status, medical illness ratings, psychiatric status, quality of life, and DSM-IV depression symptom ratings. RESULTS: The prevalence of significant general medical comorbidity in this population was 50.0% (95% CI = 48.1% to 52.0%), consistent with findings reported for the first cohort. Concurrent significant medical comorbidity was associated with older age, lower income, unemployment, limited education, and longer duration of index depressive episode. The group with significant medical comorbidity reported higher rates of somatic symptoms, gastrointestinal symptoms, sympathetic arousal, and leaden paralysis. These results were generally consistent between the 2 cohorts from STAR*D. CONCLUSIONS: Major depressive disorder with concurrent general medical conditions is associated with a specific sociodemographic profile and pattern of depressive symptoms. This association has implications for diagnosis and clinical care.

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Published In

Prim Care Companion J Clin Psychiatry

DOI

ISSN

1523-5998

Publication Date

2007

Volume

9

Issue

1

Start / End Page

7 / 15

Location

United States

Related Subject Headings

  • Psychiatry
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

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Yates, W. R., Mitchell, J., John Rush, A., Trivedi, M., Wisniewski, S. R., Warden, D., … Gaynes, B. N. (2007). Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis. Prim Care Companion J Clin Psychiatry, 9(1), 7–15. https://doi.org/10.4088/pcc.v09n0102
Yates, William R., Jeff Mitchell, A. John Rush, Madhukar Trivedi, Stephen R. Wisniewski, Diane Warden, Charlene Bryan, Maurizio Fava, Mustafa M. Husain, and Bradley N. Gaynes. “Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis.Prim Care Companion J Clin Psychiatry 9, no. 1 (2007): 7–15. https://doi.org/10.4088/pcc.v09n0102.
Yates WR, Mitchell J, John Rush A, Trivedi M, Wisniewski SR, Warden D, et al. Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis. Prim Care Companion J Clin Psychiatry. 2007;9(1):7–15.
Yates, William R., et al. “Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis.Prim Care Companion J Clin Psychiatry, vol. 9, no. 1, 2007, pp. 7–15. Pubmed, doi:10.4088/pcc.v09n0102.
Yates WR, Mitchell J, John Rush A, Trivedi M, Wisniewski SR, Warden D, Bryan C, Fava M, Husain MM, Gaynes BN. Clinical features of depression in outpatients with and without co-occurring general medical conditions in STAR*D: confirmatory analysis. Prim Care Companion J Clin Psychiatry. 2007;9(1):7–15.

Published In

Prim Care Companion J Clin Psychiatry

DOI

ISSN

1523-5998

Publication Date

2007

Volume

9

Issue

1

Start / End Page

7 / 15

Location

United States

Related Subject Headings

  • Psychiatry
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1103 Clinical Sciences