African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels.

Journal Article (Journal Article)

Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n = 83), AA (n = 56), or WAI (n = 79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = -9.8, p < 0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p < 0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.

Full Text

Duke Authors

Cited Authors

  • Annor, F; Goodman, M; Thyagarajan, B; Okosun, I; Doumatey, A; Gower, BA; Il'yasova, D

Published Date

  • 2017

Published In

Volume / Issue

  • 2017 /

Start / End Page

  • 8319176 -

PubMed ID

  • 28250893

Pubmed Central ID

  • PMC5307136

Electronic International Standard Serial Number (EISSN)

  • 1942-0994

Digital Object Identifier (DOI)

  • 10.1155/2017/8319176


  • eng

Conference Location

  • United States