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Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration?

Publication ,  Journal Article
Wong, CW; Phua, V; Lee, SY; Wong, TY; Cheung, CMG
Published in: Invest Ophthalmol Vis Sci
February 1, 2017

PURPOSE: The relative contribution of mechanical and vascular factors to the pathogenesis of myopic macular degeneration (MMD) is unclear. To address this gap, we examined the association of choroidal thickness (CT) and scleral thickness (ST) with MMD. METHODS: Prospective, clinic-based case series of 62 eyes of 41 patients with high myopia (≤-6 diopters or axial length ≥26.5 mm). Swept-source optical coherence tomography (SSOCT) was performed to measure subfoveal CT and ST. Myopic macular degeneration was graded from fundus photographs according to the International Meta-Analysis for Pathologic Myopia (META-PM) classification. Presence of MMD was defined as META-PM category ≥ 2 and severe MMD was defined as category ≥ 3. RESULTS: The distribution of MMD severity was 15 (24.2%) in category 1, 28 (45.2%) in category 2, 10 (16.1%) in category 3, and 9 (14.5%) in category 4. Correlation of MMD severity was strong for subfoveal CT (r = -0.70, P < 0.001) but weak for subfoveal ST (r = -0.31, P = 0.01). Subfoveal CT, but not ST, was independently associated with presence of MMD (age and gender adjusted odds ratio [OR] per 10 μm decrease in CT 1.41, P = 0.002), and subfoveal CT, but not subfoveal ST, was significantly thinner in eyes with severe MMD (≥ category 3) than in eyes with mild MMD (CT: 31.5 ± 40.5 μm versus 82.0 ± 57.1 μm, P < 0.001; ST: 261.6 ± 78.5 μm versus 297.0 ± 73.8 μm, P = 0.09). CONCLUSIONS: We demonstrated significant thinning of the choroid with increasing MMD severity. In contrast, ST was weakly correlated with MMD. These data suggest progressive loss of choroid may be important in the pathogenesis of MMD.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

February 1, 2017

Volume

58

Issue

2

Start / End Page

907 / 913

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Sclera
  • Refraction, Ocular
  • Prospective Studies
  • Ophthalmology & Optometry
  • Myopia, Degenerative
  • Middle Aged
  • Male
  • Macular Degeneration
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, C. W., Phua, V., Lee, S. Y., Wong, T. Y., & Cheung, C. M. G. (2017). Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? Invest Ophthalmol Vis Sci, 58(2), 907–913. https://doi.org/10.1167/iovs.16-20742
Wong, Chee Wai, Val Phua, Shu Yen Lee, Tien Yin Wong, and Chui Ming Gemmy Cheung. “Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration?Invest Ophthalmol Vis Sci 58, no. 2 (February 1, 2017): 907–13. https://doi.org/10.1167/iovs.16-20742.
Wong CW, Phua V, Lee SY, Wong TY, Cheung CMG. Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):907–13.
Wong, Chee Wai, et al. “Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration?Invest Ophthalmol Vis Sci, vol. 58, no. 2, Feb. 2017, pp. 907–13. Pubmed, doi:10.1167/iovs.16-20742.
Wong CW, Phua V, Lee SY, Wong TY, Cheung CMG. Is Choroidal or Scleral Thickness Related to Myopic Macular Degeneration? Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):907–913.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

February 1, 2017

Volume

58

Issue

2

Start / End Page

907 / 913

Location

United States

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Sclera
  • Refraction, Ocular
  • Prospective Studies
  • Ophthalmology & Optometry
  • Myopia, Degenerative
  • Middle Aged
  • Male
  • Macular Degeneration