Assessing the Causality between Blood Pressure and Retinal Vascular Caliber through Mendelian Randomisation.

Journal Article (Journal Article)

We aimed to determine the association between blood pressure (BP) and retinal vascular caliber changes that were free from confounders and reverse causation by using Mendelian randomisation. A total of 6528 participants from a multi-ethnic cohort (Chinese, Malays, and Indians) in Singapore were included in this study. Retinal arteriolar and venular caliber was measured by a semi-automated computer program. Genotyping was done using Illumina 610-quad chips. Meta-analysis of association between BP, and retinal arteriolar and venular caliber across three ethnic groups was performed both in conventional linear regression and Mendelian randomisation framework with a genetic risk score of BP as an instrumental variable. In multiple linear regression models, each 10 mm Hg increase in systolic BP, diastolic BP, and mean arterial BP (MAP) was associated with significant decreases in retinal arteriolar caliber of a 1.4, 3.0, and 2.6 μm, and significant decreases in retinal venular caliber of a 0.6, 0.7, and 0.9 μm, respectively. In a Mendelian randomisation model, only associations between DBP and MAP and retinal arteriolar narrowing remained yet its significance was greatly reduced. Our data showed weak evidence of a causal relationship between elevated BP and retinal arteriolar narrowing.

Full Text

Duke Authors

Cited Authors

  • Li, L-J; Liao, J; Cheung, CY-L; Ikram, MK; Shyong, TE; Wong, T-Y; Cheng, C-Y

Published Date

  • February 25, 2016

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 22031 -

PubMed ID

  • 26911737

Pubmed Central ID

  • PMC4766565

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep22031


  • eng

Conference Location

  • England