DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.

Journal Article (Journal Article)

Glucagon-like peptide 1 receptor (GLP-1R) signaling in the CNS has been linked to reduced food intake, lower body weight, improved glucose homeostasis, and activation of CNS stress axes. GLP-1 is produced by cells that express proglucagon (GCG); however, the stimuli that activate GCG+ neurons are not well known, which has made understanding the role of this neuronal population in the CNS a challenge. In this issue of the JCI, Gaykema et al. use designer receptors exclusively activated by designer drugs (DREADD) technology to specifically activate GCG+ neurons in mouse models. While activation of GCG+ neurons did reduce food intake, and variably decreased hepatic glucose production, other GLP-1-associated effects were not observed - e.g., activation of stress axes or stimulation of insulin secretion - in response to GCG+ neuron activation. The authors have provided a valuable model to study this set of neurons in vivo, and their results provide new insights into the function of GCG+ neural activity in the brain and raise questions that will move research on this clinically relevant neural system forward.

Full Text

Duke Authors

Cited Authors

  • Campbell, JE; D'Alessio, DA

Published Date

  • March 1, 2017

Published In

Volume / Issue

  • 127 / 3

Start / End Page

  • 793 - 795

PubMed ID

  • 28218623

Pubmed Central ID

  • PMC5330747

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI92845


  • eng

Conference Location

  • United States