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DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.

Publication ,  Journal Article
Campbell, JE; D'Alessio, DA
Published in: J Clin Invest
March 1, 2017

Glucagon-like peptide 1 receptor (GLP-1R) signaling in the CNS has been linked to reduced food intake, lower body weight, improved glucose homeostasis, and activation of CNS stress axes. GLP-1 is produced by cells that express proglucagon (GCG); however, the stimuli that activate GCG+ neurons are not well known, which has made understanding the role of this neuronal population in the CNS a challenge. In this issue of the JCI, Gaykema et al. use designer receptors exclusively activated by designer drugs (DREADD) technology to specifically activate GCG+ neurons in mouse models. While activation of GCG+ neurons did reduce food intake, and variably decreased hepatic glucose production, other GLP-1-associated effects were not observed - e.g., activation of stress axes or stimulation of insulin secretion - in response to GCG+ neuron activation. The authors have provided a valuable model to study this set of neurons in vivo, and their results provide new insights into the function of GCG+ neural activity in the brain and raise questions that will move research on this clinically relevant neural system forward.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

March 1, 2017

Volume

127

Issue

3

Start / End Page

793 / 795

Location

United States

Related Subject Headings

  • Proglucagon
  • Neurons
  • Mice
  • Immunology
  • Humans
  • Glucagon-Like Peptide-1 Receptor
  • Drug Design
  • Brain
  • Animals
  • 42 Health sciences
 

Citation

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Campbell, J. E., & D’Alessio, D. A. (2017). DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain. J Clin Invest, 127(3), 793–795. https://doi.org/10.1172/JCI92845
Campbell, Jonathan E., and David A. D’Alessio. “DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.J Clin Invest 127, no. 3 (March 1, 2017): 793–95. https://doi.org/10.1172/JCI92845.
Campbell JE, D’Alessio DA. DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain. J Clin Invest. 2017 Mar 1;127(3):793–5.
Campbell, Jonathan E., and David A. D’Alessio. “DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain.J Clin Invest, vol. 127, no. 3, Mar. 2017, pp. 793–95. Pubmed, doi:10.1172/JCI92845.
Campbell JE, D’Alessio DA. DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain. J Clin Invest. 2017 Mar 1;127(3):793–795.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

March 1, 2017

Volume

127

Issue

3

Start / End Page

793 / 795

Location

United States

Related Subject Headings

  • Proglucagon
  • Neurons
  • Mice
  • Immunology
  • Humans
  • Glucagon-Like Peptide-1 Receptor
  • Drug Design
  • Brain
  • Animals
  • 42 Health sciences