Cytokine biomarkers in tear film for primary open-angle glaucoma.

Journal Article (Journal Article)

PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα). RESULTS: Mean concentrations of tear film cytokines were lower in the glaucoma group for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL in POAG; P=0.035) was significantly lower in the tear film of patients with newly diagnosed POAG. CONCLUSION: Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early POAG.

Full Text

Duke Authors

Cited Authors

  • Gupta, D; Wen, JC; Huebner, JL; Stinnett, S; Kraus, VB; Tseng, HC; Walsh, M

Published Date

  • 2017

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 411 - 416

PubMed ID

  • 28260854

Pubmed Central ID

  • PMC5328319

International Standard Serial Number (ISSN)

  • 1177-5467

Digital Object Identifier (DOI)

  • 10.2147/OPTH.S125364


  • eng

Conference Location

  • New Zealand