Reassortment of pandemic H1N1/2009 influenza A virus in swine.


Journal Article

The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries. Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, we characterize a reassortant progeny of H1N1/2009 with swine viruses. Swine experimentally infected with this reassortant developed mild illness and transmitted infection to contact animals. Continued reassortment of H1N1/2009 with swine influenza viruses could produce variants with transmissibility and altered virulence for humans. Global systematic surveillance of influenza viruses in swine is warranted.

Full Text

Cited Authors

  • Vijaykrishna, D; Poon, LLM; Zhu, HC; Ma, SK; Li, OTW; Cheung, CL; Smith, GJD; Peiris, JSM; Guan, Y

Published Date

  • June 2010

Published In

Volume / Issue

  • 328 / 5985

Start / End Page

  • 1529 -

PubMed ID

  • 20558710

Pubmed Central ID

  • 20558710

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1189132


  • eng