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The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.

Publication ,  Journal Article
Thomas, S; Izard, J; Walsh, E; Batich, K; Chongsathidkiet, P; Clarke, G; Sela, DA; Muller, AJ; Mullin, JM; Albert, K; Gilligan, JP ...
Published in: Cancer research
April 2017

Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make essential contributions to human health and well being. Each person is inhabited and also surrounded by his/her own signature microbial cloud. A low diversity of microorganisms is associated with a plethora of diseases, including allergy, diabetes, obesity, arthritis, inflammatory bowel diseases, and even neuropsychiatric disorders. Thus, an interaction of microorganisms with the host immune system is required for a healthy body. Exposure to microorganisms from the moment we are born and appropriate microbiome assembly during childhood are essential for establishing an active immune system necessary to prevent disease later in life. Exposure to microorganisms educates the immune system, induces adaptive immunity, and initiates memory B and T cells that are essential to combat various pathogens. The correct microbial-based education of immune cells may be critical in preventing the development of autoimmune diseases and cancer. This review provides a broad overview of the importance of the host microbiome and accumulating knowledge of how it regulates and maintains a healthy human system. Cancer Res; 77(8); 1783-812. ©2017 AACR.

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Published In

Cancer research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

April 2017

Volume

77

Issue

8

Start / End Page

1783 / 1812

Related Subject Headings

  • Oncology & Carcinogenesis
  • Microbiota
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Thomas, S., Izard, J., Walsh, E., Batich, K., Chongsathidkiet, P., Clarke, G., … Prendergast, G. C. (2017). The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Cancer Research, 77(8), 1783–1812. https://doi.org/10.1158/0008-5472.can-16-2929
Thomas, Sunil, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, et al. “The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Cancer Research 77, no. 8 (April 2017): 1783–1812. https://doi.org/10.1158/0008-5472.can-16-2929.
Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, et al. The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Cancer research. 2017 Apr;77(8):1783–812.
Thomas, Sunil, et al. “The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.Cancer Research, vol. 77, no. 8, Apr. 2017, pp. 1783–812. Epmc, doi:10.1158/0008-5472.can-16-2929.
Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, Sela DA, Muller AJ, Mullin JM, Albert K, Gilligan JP, DiGuilio K, Dilbarova R, Alexander W, Prendergast GC. The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Cancer research. 2017 Apr;77(8):1783–1812.

Published In

Cancer research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

April 2017

Volume

77

Issue

8

Start / End Page

1783 / 1812

Related Subject Headings

  • Oncology & Carcinogenesis
  • Microbiota
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis