Endovascular Repair of Internal Mammary Artery Aneurysms in 2 Sisters with SMAD3 Mutation.


Journal Article

True aneurysms of the internal mammary artery are rare and have been described in association with vasculitis or connective tissue disorders. Herein, we describe 2 cases of familial internal mammary artery aneurysms (IMAs) in 2 sisters with SMAD3 mutation. The older sister presented at the age of 54 years with an incidental diagnosis of a multilobed right IMA and the younger sister presented several years earlier with a ruptured left IMA aneurysm at the age of 49 years. Both sisters had Debakey type I aortic dissections prior to the IMA aneurysm presentation. To our knowledge, this is the first time IMA aneurysms have been described in siblings with SMAD3 mutation. In our experience, endovascular repair is a feasible and safe treatment option. An assessment of the entire arterial tree is recommended in patients diagnosed with SMAD3 mutations.

Full Text

Cited Authors

  • Nevidomskyte, D; Shalhub, S; Aldea, GS; Byers, PH; Schwarze, U; Murray, ML; Starnes, B

Published Date

  • May 2017

Published In

Volume / Issue

  • 41 /

Start / End Page

  • 283.e5 - 283.e9

PubMed ID

  • 28286188

Pubmed Central ID

  • 28286188

Electronic International Standard Serial Number (EISSN)

  • 1615-5947

Digital Object Identifier (DOI)

  • 10.1016/j.avsg.2016.10.048


  • eng

Conference Location

  • Netherlands