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Coded Apertures in Mass Spectrometry.

Publication ,  Journal Article
Amsden, JJ; Gehm, ME; Russell, ZE; Chen, EX; Di Dona, ST; Wolter, SD; Danell, RM; Kibelka, G; Parker, CB; Stoner, BR; Brady, DJ; Glass, JT
Published in: Annual review of analytical chemistry (Palo Alto, Calif.)
June 2017

The use of coded apertures in mass spectrometry can break the trade-off between throughput and resolution that has historically plagued conventional instruments. Despite their very early stage of development, coded apertures have been shown to increase throughput by more than one order of magnitude, with no loss in resolution in a simple 90-degree magnetic sector. This enhanced throughput can increase the signal level with respect to the underlying noise, thereby significantly improving sensitivity to low concentrations of analyte. Simultaneous resolution can be maintained, preventing any decrease in selectivity. Both one- and two-dimensional (2D) codes have been demonstrated. A 2D code can provide increased measurement diversity and therefore improved numerical conditioning of the mass spectrum that is reconstructed from the coded signal. This review discusses the state of development, the applications where coding is expected to provide added value, and the various instrument modifications necessary to implement coded apertures in mass spectrometers.

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Published In

Annual review of analytical chemistry (Palo Alto, Calif.)

DOI

EISSN

1936-1335

ISSN

1936-1327

Publication Date

June 2017

Volume

10

Issue

1

Start / End Page

141 / 156

Related Subject Headings

  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0399 Other Chemical Sciences
  • 0301 Analytical Chemistry
 

Citation

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Amsden, J. J., Gehm, M. E., Russell, Z. E., Chen, E. X., Di Dona, S. T., Wolter, S. D., … Glass, J. T. (2017). Coded Apertures in Mass Spectrometry. Annual Review of Analytical Chemistry (Palo Alto, Calif.), 10(1), 141–156. https://doi.org/10.1146/annurev-anchem-061516-045256
Amsden, Jason J., Michael E. Gehm, Zachary E. Russell, Evan X. Chen, Shane T. Di Dona, Scott D. Wolter, Ryan M. Danell, et al. “Coded Apertures in Mass Spectrometry.Annual Review of Analytical Chemistry (Palo Alto, Calif.) 10, no. 1 (June 2017): 141–56. https://doi.org/10.1146/annurev-anchem-061516-045256.
Amsden JJ, Gehm ME, Russell ZE, Chen EX, Di Dona ST, Wolter SD, et al. Coded Apertures in Mass Spectrometry. Annual review of analytical chemistry (Palo Alto, Calif). 2017 Jun;10(1):141–56.
Amsden, Jason J., et al. “Coded Apertures in Mass Spectrometry.Annual Review of Analytical Chemistry (Palo Alto, Calif.), vol. 10, no. 1, June 2017, pp. 141–56. Epmc, doi:10.1146/annurev-anchem-061516-045256.
Amsden JJ, Gehm ME, Russell ZE, Chen EX, Di Dona ST, Wolter SD, Danell RM, Kibelka G, Parker CB, Stoner BR, Brady DJ, Glass JT. Coded Apertures in Mass Spectrometry. Annual review of analytical chemistry (Palo Alto, Calif). 2017 Jun;10(1):141–156.

Published In

Annual review of analytical chemistry (Palo Alto, Calif.)

DOI

EISSN

1936-1335

ISSN

1936-1327

Publication Date

June 2017

Volume

10

Issue

1

Start / End Page

141 / 156

Related Subject Headings

  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0399 Other Chemical Sciences
  • 0301 Analytical Chemistry