5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.

Journal Article (Journal Article)

Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1-3 (TET1-3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.

Full Text

Duke Authors

Cited Authors

  • Chamessian, AG; Qadri, YJ; Cummins, M; Hendrickson, M; Berta, T; Buchheit, T; Van de Ven, T

Published Date

  • June 2017

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 72 - 79

PubMed ID

  • 28276837

Pubmed Central ID

  • PMC5818713

Electronic International Standard Serial Number (EISSN)

  • 1369-1651

Digital Object Identifier (DOI)

  • 10.1080/08990220.2017.1292237


  • eng

Conference Location

  • England