Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.

Journal Article (Review;Journal Article)

Imaging genetics and genomics research has begun to provide insight into the molecular and genetic architecture of neural phenotypes and the neural mechanisms through which genetic risk for psychopathology may emerge. As it approaches its third decade, imaging genetics is confronted by many challenges, including the proliferation of studies using small sample sizes and diverse designs, limited replication, problems with harmonization of neural phenotypes for meta-analysis, unclear mechanisms, and evidence that effect sizes may be more modest than originally posited, with increasing evidence of polygenicity. These concerns have encouraged the field to grow in many new directions, including the development of consortia and large-scale data collection projects and the use of novel methods (e.g., polygenic approaches, machine learning) that enhance the quality of imaging genetic studies but also introduce new challenges. We critically review progress in imaging genetics and offer suggestions and highlight potential pitfalls of novel approaches. Ultimately, the strength of imaging genetics and genomics lies in their translational and integrative potential with other research approaches (e.g., nonhuman animal models, psychiatric genetics, pharmacologic challenge) to elucidate brain-based pathways that give rise to the vast individual differences in behavior as well as risk for psychopathology.

Full Text

Duke Authors

Cited Authors

  • Bogdan, R; Salmeron, BJ; Carey, CE; Agrawal, A; Calhoun, VD; Garavan, H; Hariri, AR; Heinz, A; Hill, MN; Holmes, A; Kalin, NH; Goldman, D

Published Date

  • August 2017

Published In

Volume / Issue

  • 82 / 3

Start / End Page

  • 165 - 175

PubMed ID

  • 28283186

Pubmed Central ID

  • PMC5505787

Electronic International Standard Serial Number (EISSN)

  • 1873-2402

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2016.12.030


  • eng