Bioengineered hemodialysis access grafts.

Published

Journal Article (Review)

There is a need for bioengineered therapies to improve the overall health of the growing and aging world population. Patients with renal failure have a life-long requirement for a durable form of hemodialysis vascular access. In this article, we review the history of tissue engineering as it pertains to bioengineered grafts and vessels for hemodialysis access. Over the years, various strategies have been utilized to develop ideal, humanized vessels for vascular replacement such as fixation of animal or human vessels, cell seeding of synthetic materials, and the synthesis of completely autologous or allogeneic bioengineered vessels. Tissue engineering technologies from two companies have progressed to reach phase 2 and phase 3 clinical trials, but the prospect of newer strategies on the horizon may offer improved manufacturing efficiency, a greater variety of conduit size and length, and reduce the cost to produce.

Full Text

Duke Authors

Cited Authors

  • Gage, SM; Lawson, JH

Published Date

  • March 5, 2017

Published In

Volume / Issue

  • 18 / Suppl. 1

Start / End Page

  • 56 - 63

PubMed ID

  • 28297061

Pubmed Central ID

  • 28297061

Electronic International Standard Serial Number (EISSN)

  • 1724-6032

International Standard Serial Number (ISSN)

  • 1129-7298

Digital Object Identifier (DOI)

  • 10.5301/jva.5000692

Language

  • eng