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Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.

Publication ,  Journal Article
Pan, Y; Liu, H; Wang, Y; Kang, X; Liu, Z; Owzar, K; Han, Y; Su, L; Wei, Y; Hung, RJ; Brhane, Y; McLaughlin, J; Brennan, P; Bickeböller, H ...
Published in: Sci Rep
March 17, 2017

mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls). We found that a total of 12 significant SNPs with false discovery rate (FDR) ≤0.05 were mapped to one novel gene PRPF6 and two previously reported genes (DHX16 and LSM2) that were also confirmed in this study. The six novel SNPs in PRPF6 were in high linkage disequilibrium and associated with PRPF6 mRNA expression in lymphoblastoid cells from 373 Europeans in the 1000 Genomes Project. Taken together, our studies shed new light on the role of mRNA splicing genes in the development of lung cancer.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

March 17, 2017

Volume

7

Start / End Page

44634

Location

England

Related Subject Headings

  • Risk Factors
  • Reproducibility of Results
  • RNA, Messenger
  • RNA Splicing
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Molecular Sequence Annotation
  • Lung Neoplasms
  • Linkage Disequilibrium
  • Humans
 

Citation

APA
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Pan, Y., Liu, H., Wang, Y., Kang, X., Liu, Z., Owzar, K., … Wei, Q. (2017). Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep, 7, 44634. https://doi.org/10.1038/srep44634
Pan, Yongchu, Hongliang Liu, Yanru Wang, Xiaozheng Kang, Zhensheng Liu, Kouros Owzar, Younghun Han, et al. “Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.Sci Rep 7 (March 17, 2017): 44634. https://doi.org/10.1038/srep44634.
Pan, Yongchu, et al. “Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.Sci Rep, vol. 7, Mar. 2017, p. 44634. Pubmed, doi:10.1038/srep44634.
Pan Y, Liu H, Wang Y, Kang X, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeböller H, Rosenberger A, Houlston RS, Caporaso N, Teresa Landi M, Heinrich J, Risch A, Wu X, Ye Y, Christiani DC, Amos CI, Wei Q. Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep. 2017 Mar 17;7:44634.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

March 17, 2017

Volume

7

Start / End Page

44634

Location

England

Related Subject Headings

  • Risk Factors
  • Reproducibility of Results
  • RNA, Messenger
  • RNA Splicing
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Molecular Sequence Annotation
  • Lung Neoplasms
  • Linkage Disequilibrium
  • Humans