Hepatocellular adenoma among adult survivors of childhood and young adult cancer.

Journal Article (Journal Article)

Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified 12 cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N = 4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All 11 females had prior estrogen therapy; the male case was hypogonadal. This report suggests childhood and young adult cancer survivors may be at increased risk for HCA, but further investigation is needed.

Full Text

Duke Authors

Cited Authors

  • Tonorezos, ES; Barnea, D; Abou-Alfa, GK; Bromberg, J; D'Angelica, M; Sklar, CA; Shia, J; Oeffinger, KC

Published Date

  • April 2017

Published In

Volume / Issue

  • 64 / 4

PubMed ID

  • 27781382

Pubmed Central ID

  • PMC5477223

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.26294


  • eng

Conference Location

  • United States