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Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study.

Publication ,  Journal Article
Friedman, DN; Chou, JF; Oeffinger, KC; Kleinerman, RA; Ford, JS; Sklar, CA; Li, Y; McCabe, MS; Robison, LL; Marr, BP; Abramson, DH; Dunkel, IJ
Published in: Cancer
March 1, 2016

BACKGROUND: Limited data are available regarding long-term morbidity in adult survivors of retinoblastoma (Rb). METHODS: The Retinoblastoma Survivor Study is a retrospective cohort of adult survivors of Rb diagnosed between 1932 and 1994. Participants completed a comprehensive questionnaire adapted from the Childhood Cancer Survivor Study surveys. Chronic conditions were classified using the National Cancer Institute's Common Terminology Criteria for Adverse Events (version 4.03). Multivariate Poisson regression was used to compare survivors of Rb with 2377 non-Rb controls, consisting of the Childhood Cancer Survivor Study sibling cohort and survivors with bilateral versus unilateral disease. RESULTS: Survivors of Rb (53.6% with bilateral disease) and non-Rb controls had a mean age of 43.3 years (standard deviation, 11 years) and 37.6 years (SD, 8.6 years), respectively, at the time of study enrollment. At a median follow-up of 42 years (range, 15-75 years), 86.6% of survivors of Rb had at least 1 condition and 71.1% had a severe/life-threatening (grade 3-4) condition. The adjusted relative risk (RR) of a chronic condition in survivors compared with non-Rb controls was 1.4 (95% confidence interval [95% CI], 1.3-1.4; P<.01); for a grade 3 to 4 condition, the RR was 7.6 (95% CI, 6.4-8.9; P<.01). Survivors were at an excess risk regardless of laterality. After stratifying by laterality and excluding ocular conditions and second malignant neoplasms (SMNs), only those with bilateral disease were found to be at an increased risk of any nonocular, non-SMN condition (RR, 1.2; 95% CI, 1.1-1.2) and for grade 3 to 4 nonocular, non-SMN conditions (RR, 1.7; 95% CI, 1.2-2.5). CONCLUSIONS: Survivors of Rb have an increased risk of chronic conditions compared with non-Rb controls. After excluding ocular conditions and SMNs, this excess risk was found to persist only for those with bilateral disease. Cancer 2016;122:773-781. © 2016 American Cancer Society.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

March 1, 2016

Volume

122

Issue

5

Start / End Page

773 / 781

Location

United States

Related Subject Headings

  • Vision Disorders
  • Thyroid Nodule
  • Survivors
  • Stroke
  • Retrospective Studies
  • Retinoblastoma
  • Retinal Neoplasms
  • Regression Analysis
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
 

Citation

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Friedman, D. N., Chou, J. F., Oeffinger, K. C., Kleinerman, R. A., Ford, J. S., Sklar, C. A., … Dunkel, I. J. (2016). Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study. Cancer, 122(5), 773–781. https://doi.org/10.1002/cncr.29704
Friedman, Danielle Novetsky, Joanne F. Chou, Kevin C. Oeffinger, Ruth A. Kleinerman, Jennifer S. Ford, Charles A. Sklar, Yuelin Li, et al. “Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study.Cancer 122, no. 5 (March 1, 2016): 773–81. https://doi.org/10.1002/cncr.29704.
Friedman DN, Chou JF, Oeffinger KC, Kleinerman RA, Ford JS, Sklar CA, et al. Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study. Cancer. 2016 Mar 1;122(5):773–81.
Friedman, Danielle Novetsky, et al. “Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study.Cancer, vol. 122, no. 5, Mar. 2016, pp. 773–81. Pubmed, doi:10.1002/cncr.29704.
Friedman DN, Chou JF, Oeffinger KC, Kleinerman RA, Ford JS, Sklar CA, Li Y, McCabe MS, Robison LL, Marr BP, Abramson DH, Dunkel IJ. Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study. Cancer. 2016 Mar 1;122(5):773–781.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

March 1, 2016

Volume

122

Issue

5

Start / End Page

773 / 781

Location

United States

Related Subject Headings

  • Vision Disorders
  • Thyroid Nodule
  • Survivors
  • Stroke
  • Retrospective Studies
  • Retinoblastoma
  • Retinal Neoplasms
  • Regression Analysis
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary