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Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial.

Publication ,  Journal Article
Hudson, MM; Leisenring, W; Stratton, KK; Tinner, N; Steen, BD; Ogg, S; Barnes, L; Oeffinger, KC; Robison, LL; Cox, CL
Published in: J Clin Oncol
December 10, 2014

PURPOSE: To determine whether the addition of advanced-practice nurse (APN) telephone counseling to a printed survivorship care plan (SCP) significantly increases the proportion of at-risk survivors who complete cardiomyopathy screening. PATIENTS AND METHODS: Survivors age ≥ 25 years participating in the Childhood Cancer Survivor Study who received cardiotoxic therapy and reported no history of cardiomyopathy screening in the previous 5 years were eligible for enrollment. The 472 participants (mean age, 40.1 years; range, 25.0 to 59.0; 53.3% women) were randomly assigned to either standard care, consisting of an SCP summarizing cancer treatment and cardiac health screening recommendations (n = 234), or standard care plus two APN telephone counseling sessions (n = 238). The primary outcome-completion of cardiomyopathy screening within 1 year-was validated by medical records and compared between the two arms using adjusted relative risks (RRs) with 95% CIs. RESULTS: Participants in the standard and APN counseling groups were not statistically different by demographic or clinical characteristics. At the time of 1-year follow-up, 107 (52.2%) of 205 survivors in the APN group completed screening compared with 46 (22.3%) of 206 survivors in the non-APN group (P < .001). With adjustment for sex, age (< 30 v ≥ 30 years), and Children's Oncology Group-recommended screening frequency group (annual, 2 years, or 5 years), survivors in the APN group were > 2× more likely than those in the control group to complete the recommended cardiomyopathy screening (RR, 2.31; 95% CI, 1.74 to 3.07). CONCLUSION: The addition of telephone counseling to an SCP with cardiac health screening recommendations increases cardiomyopathy screening in at-risk survivors.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

December 10, 2014

Volume

32

Issue

35

Start / End Page

3974 / 3981

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Telemedicine
  • Survivors
  • Survival Rate
  • Risk
  • Oncology & Carcinogenesis
  • Neoplasms
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hudson, M. M., Leisenring, W., Stratton, K. K., Tinner, N., Steen, B. D., Ogg, S., … Cox, C. L. (2014). Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial. J Clin Oncol, 32(35), 3974–3981. https://doi.org/10.1200/JCO.2014.57.3493
Hudson, Melissa M., Wendy Leisenring, Kayla K. Stratton, Nina Tinner, Brenda D. Steen, Susan Ogg, Linda Barnes, Kevin C. Oeffinger, Leslie L. Robison, and Cheryl L. Cox. “Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial.J Clin Oncol 32, no. 35 (December 10, 2014): 3974–81. https://doi.org/10.1200/JCO.2014.57.3493.
Hudson MM, Leisenring W, Stratton KK, Tinner N, Steen BD, Ogg S, et al. Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial. J Clin Oncol. 2014 Dec 10;32(35):3974–81.
Hudson, Melissa M., et al. “Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial.J Clin Oncol, vol. 32, no. 35, Dec. 2014, pp. 3974–81. Pubmed, doi:10.1200/JCO.2014.57.3493.
Hudson MM, Leisenring W, Stratton KK, Tinner N, Steen BD, Ogg S, Barnes L, Oeffinger KC, Robison LL, Cox CL. Increasing cardiomyopathy screening in at-risk adult survivors of pediatric malignancies: a randomized controlled trial. J Clin Oncol. 2014 Dec 10;32(35):3974–3981.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

December 10, 2014

Volume

32

Issue

35

Start / End Page

3974 / 3981

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Telemedicine
  • Survivors
  • Survival Rate
  • Risk
  • Oncology & Carcinogenesis
  • Neoplasms
  • Middle Aged
  • Male
  • Humans