Are survivors of acute lymphoblastic leukemia (ALL) at increased risk of cardiovascular disease?


Journal Article (Review)

Through a variety of different mechanisms, it appears that survivors of childhood acute lymphoblastic leukemia have an increased prevalence of several cardiovascular risk factors and thus are at increased risk for developing cardiovascular disease. The aim of this paper is to describe the current understanding of particular risk factors, including obesity, physical inactivity, dyslipidemia, insulin resistance, and metabolic syndrome, that may contribute to cardiovascular disease in survivors of childhood ALL. The potential roles of different cancer therapies in the development of these risk factors are discussed. In addition, two other late effects that may affect cardiovascular health are discussed: late-onset anthracycline-induced left ventricular dysfunction and methotrexate-mediated elevations of homocysteine during therapy with the potential for endothelial dysfunction. Lastly, areas needing further investigation to elucidate these risks are highlighted.

Full Text

Duke Authors

Cited Authors

  • Oeffinger, KC

Published Date

  • February 2008

Published In

Volume / Issue

  • 50 / 2 Suppl

Start / End Page

  • 462 - 467

PubMed ID

  • 18064658

Pubmed Central ID

  • 18064658

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.21410


  • eng

Conference Location

  • United States