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Testicular cancer survivorship: research strategies and recommendations.

Publication ,  Journal Article
Travis, LB; Beard, C; Allan, JM; Dahl, AA; Feldman, DR; Oldenburg, J; Daugaard, G; Kelly, JL; Dolan, ME; Hannigan, R; Constine, LS; Wiljer, D ...
Published in: J Natl Cancer Inst
August 4, 2010

Testicular cancer represents the most curable solid tumor, with a 10-year survival rate of more than 95%. Given the young average age at diagnosis, it is estimated that effective treatment approaches, in particular, platinum-based chemotherapy, have resulted in an average gain of several decades of life. This success, however, is offset by the emergence of considerable long-term morbidity, including second malignant neoplasms, cardiovascular disease, neurotoxicity, nephrotoxicity, pulmonary toxicity, hypogonadism, decreased fertility, and psychosocial problems. Data on underlying genetic or molecular factors that might identify those patients at highest risk for late sequelae are sparse. Genome-wide association studies and other translational molecular approaches now provide opportunities to identify testicular cancer survivors at greatest risk for therapy-related complications to develop evidence-based long-term follow-up guidelines and interventional strategies. We review research priorities identified during an international workshop devoted to testicular cancer survivors. Recommendations include 1) institution of lifelong follow-up of testicular cancer survivors within a large cohort setting to ascertain risks of emerging toxicities and the evolution of known late sequelae, 2) development of comprehensive risk prediction models that include treatment factors and genetic modifiers of late sequelae, 3) elucidation of the effect(s) of decades-long exposure to low serum levels of platinum, 4) assessment of the overall burden of medical and psychosocial morbidity, and 5) the eventual formulation of evidence-based long-term follow-up guidelines and interventions. Just as testicular cancer once served as the paradigm of a curable malignancy, comprehensive follow-up studies of testicular cancer survivors can pioneer new methodologies in survivorship research for all adult-onset cancer.

Duke Scholars

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

August 4, 2010

Volume

102

Issue

15

Start / End Page

1114 / 1130

Location

United States

Related Subject Headings

  • Young Adult
  • Testicular Neoplasms
  • Survivors
  • Survival Rate
  • Risk Assessment
  • Renal Insufficiency
  • Quality of Life
  • Pulmonary Fibrosis
  • Population Surveillance
  • Platinum Compounds
 

Citation

APA
Chicago
ICMJE
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Travis, L. B., Beard, C., Allan, J. M., Dahl, A. A., Feldman, D. R., Oldenburg, J., … Fossa, S. D. (2010). Testicular cancer survivorship: research strategies and recommendations. J Natl Cancer Inst, 102(15), 1114–1130. https://doi.org/10.1093/jnci/djq216
Travis, Lois B., Clair Beard, James M. Allan, Alv A. Dahl, Darren R. Feldman, Jan Oldenburg, Gedske Daugaard, et al. “Testicular cancer survivorship: research strategies and recommendations.J Natl Cancer Inst 102, no. 15 (August 4, 2010): 1114–30. https://doi.org/10.1093/jnci/djq216.
Travis LB, Beard C, Allan JM, Dahl AA, Feldman DR, Oldenburg J, et al. Testicular cancer survivorship: research strategies and recommendations. J Natl Cancer Inst. 2010 Aug 4;102(15):1114–30.
Travis, Lois B., et al. “Testicular cancer survivorship: research strategies and recommendations.J Natl Cancer Inst, vol. 102, no. 15, Aug. 2010, pp. 1114–30. Pubmed, doi:10.1093/jnci/djq216.
Travis LB, Beard C, Allan JM, Dahl AA, Feldman DR, Oldenburg J, Daugaard G, Kelly JL, Dolan ME, Hannigan R, Constine LS, Oeffinger KC, Okunieff P, Armstrong G, Wiljer D, Miller RC, Gietema JA, van Leeuwen FE, Williams JP, Nichols CR, Einhorn LH, Fossa SD. Testicular cancer survivorship: research strategies and recommendations. J Natl Cancer Inst. 2010 Aug 4;102(15):1114–1130.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

August 4, 2010

Volume

102

Issue

15

Start / End Page

1114 / 1130

Location

United States

Related Subject Headings

  • Young Adult
  • Testicular Neoplasms
  • Survivors
  • Survival Rate
  • Risk Assessment
  • Renal Insufficiency
  • Quality of Life
  • Pulmonary Fibrosis
  • Population Surveillance
  • Platinum Compounds