TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.
Journal Article (Journal Article)
Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea. However, signaling mechanisms causing increased expression of TRPV4 await elucidation. Moreover, we ask whether TRPV4-mediated Ca++-influx evokes mast cell degranulation.
Full Text
Duke Authors
- Chen, Yong
- Hall III, Russell P.
- Liedtke, Wolfgang Bernhard
- MacLeod, Amanda S
- Moore, Carlene D
- Zhang, Jennifer Yunyan
Cited Authors
- Chen, Y; Moore, CD; Zhang, JY; Hall, RP; MacLeod, AS; Liedtke, W
Published Date
- April 2017
Published In
Volume / Issue
- 137 / 4
Start / End Page
- 801 - 804
PubMed ID
- 28340683
Pubmed Central ID
- PMC5536341
Electronic International Standard Serial Number (EISSN)
- 1523-1747
Digital Object Identifier (DOI)
- 10.1016/j.jid.2016.12.013
Language
- eng
Conference Location
- United States