TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

Journal Article (Journal Article)

Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 a translational-medical target in rosacea. However, signaling mechanisms causing increased expression of TRPV4 await elucidation. Moreover, we ask whether TRPV4-mediated Ca++ -influx evokes mast cell degranulation.

Full Text

Duke Authors

Cited Authors

  • Chen, Y; Moore, CD; Zhang, JY; Hall, RP; MacLeod, AS; Liedtke, W

Published Date

  • April 2017

Published In

Volume / Issue

  • 137 / 4

Start / End Page

  • 801 - 804

PubMed ID

  • 28340683

Pubmed Central ID

  • PMC5536341

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

International Standard Serial Number (ISSN)

  • 0022-202X

Digital Object Identifier (DOI)

  • 10.1016/j.jid.2016.12.013


  • eng