Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.

Published online

Journal Article

The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases and 2,564 controls of European ancestry, followed by replication and meta-analysis, for a total of 2,075 cases and 3,342 controls. We identify three novel loci meeting genome-wide significance (P<5 × 10-8): KANK4 rs79742895, LAMC1 rs3768617 and LINC00970/ATP1B1 rs1200114. We also observe an overwhelming effect of the established TCF4 locus. Interestingly, we detect differential sex-specific association at LAMC1, with greater risk in women, and TCF4, with greater risk in men. Combining GWAS results with biological evidence we expand the knowledge of common FECD loci from one to four, and provide a deeper understanding of the underlying pathogenic basis of FECD.

Full Text

Duke Authors

Cited Authors

  • Afshari, NA; Igo, RP; Morris, NJ; Stambolian, D; Sharma, S; Pulagam, VL; Dunn, S; Stamler, JF; Truitt, BJ; Rimmler, J; Kuot, A; Croasdale, CR; Qin, X; Burdon, KP; Riazuddin, SA; Mills, R; Klebe, S; Minear, MA; Zhao, J; Balajonda, E; Rosenwasser, GO; Baratz, KH; Mootha, VV; Patel, SV; Gregory, SG; Bailey-Wilson, JE; Price, MO; Price, FW; Craig, JE; Fingert, JH; Gottsch, JD; Aldave, AJ; Klintworth, GK; Lass, JH; Li, Y-J; Iyengar, SK

Published Date

  • March 30, 2017

Published In

Volume / Issue

  • 8 /

Start / End Page

  • 14898 -

PubMed ID

  • 28358029

Pubmed Central ID

  • 28358029

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms14898

Language

  • eng

Conference Location

  • England