Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility.

Journal Article (Journal Article;Review)

Cell polarity is fundamental to the function of most cells. The evolutionarily conserved molecular machinery that controls cell polarity is centered on a family of GTPases related to Cdc42. Cdc42 becomes activated and concentrated at polarity sites, but studies in yeast model systems led to controversy on the mechanisms of polarization. Here we review recent studies that have clarified how Cdc42 becomes polarized in yeast. On one hand, findings that appeared to support a key role for the actin cytoskeleton and vesicle traffic in polarity establishment now appear to reflect the action of stress response pathways induced by cytoskeletal perturbations. On the other hand, new findings strongly support hypotheses on the polarization mechanism whose origins date back to the mathematician Alan Turing. The key features of the polarity establishment mechanism in yeasts include a positive feedback pathway in which active Cdc42 recruits a Cdc42 activator to polarity sites, and differential mobility of polarity "activators" and "substrates."

Full Text

Duke Authors

Cited Authors

  • Woods, B; Lew, DJ

Published Date

  • March 2019

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 130 - 137

PubMed ID

  • 28350208

Pubmed Central ID

  • PMC6380280

Electronic International Standard Serial Number (EISSN)

  • 2154-1256

Digital Object Identifier (DOI)

  • 10.1080/21541248.2016.1275370


  • eng

Conference Location

  • United States