Droplet Size-Aware High-Level Synthesis for Micro-Electrode-Dot-Array Digital Microfluidic Biochips.

Published

Journal Article

A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. In recent years, DMFBs based on a microelectrode-dot-array (MEDA) architecture have been demonstrated. However, due to the inherent differences between today's DMFBs and MEDA, existing synthesis solutions for biochemistry mapping cannot be utilized for MEDA biochips. We present the first synthesis approach that can be used for MEDA biochips. We first present a general analytical model for droplet velocity and validate it experimentally using a fabricated MEDA biochip. We then present the proposed synthesis method targeting reservoir placement, operation scheduling, module placement, routing of droplets of various sizes, and diagonal movement of droplets in a two-dimensional array. Simulation results using benchmarks and experimental results using a fabricated MEDA biochip demonstrate the effectiveness of the proposed synthesis technique.

Full Text

Duke Authors

Cited Authors

  • Li, Z; Lai, KY-T; Yu, P-H; Chakrabarty, K; Ho, T-Y; Lee, C-Y

Published Date

  • June 2017

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 612 - 626

PubMed ID

  • 28333641

Pubmed Central ID

  • 28333641

Electronic International Standard Serial Number (EISSN)

  • 1940-9990

International Standard Serial Number (ISSN)

  • 1932-4545

Digital Object Identifier (DOI)

  • 10.1109/tbcas.2017.2653808

Language

  • eng