High-Dose Interleukin-2: Evaluation of a Standardized Order Set for Biotherapy in an Intensive Care Unit
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Journal Article (Journal Article)

Background

Life-threatening toxicity may result from administration of high-dose (HD) interleukin-2 (IL-2). Patients receiving HD IL-2 treatment often experience severe adverse side effects, which result in the interruption of treatment. 
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Objectives

A standardized order set (SOS) was developed for patients with melanoma or renal cell carcinoma receiving HD IL-2. The aims of the study were to determine compliance of clinicians to the SOS, report the completed doses and major side effects of HD IL-2, and document the satisfaction level of clinicians.
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Methods

A retrospective chart review of 40 health records of patients with melanoma or renal cell carcinoma who were treated with HD IL-2 was conducted to determine compliance to the SOS. Staff satisfaction with the SOS was surveyed.
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Findings

The SOS was successfully implemented with a provider compliance rate of 90%. Cardiovascular side effects were the most common. Clinicians found the SOS very satisfactory or superior in guiding care and treatment of side effects.

Full Text

Duke Authors

Cited Authors

  • Portillas, R; Turner, B; Jeffers, A; Chen, L-L; Champagne, M

Published Date

  • April 2017

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • E49 - E53

PubMed ID

  • 28315535

Electronic International Standard Serial Number (EISSN)

  • 1538-067X

International Standard Serial Number (ISSN)

  • 1092-1095

Digital Object Identifier (DOI)

  • 10.1188/17.cjon.e49-e53

Language

  • eng