High-Dose Interleukin-2: Evaluation of a Standardized Order Set for Biotherapy in an Intensive Care Unit .
Journal Article (Journal Article)
Background
Life-threatening toxicity may result from administration of high-dose (HD) interleukin-2 (IL-2). Patients receiving HD IL-2 treatment often experience severe adverse side effects, which result in the interruption of treatment. .Objectives
A standardized order set (SOS) was developed for patients with melanoma or renal cell carcinoma receiving HD IL-2. The aims of the study were to determine compliance of clinicians to the SOS, report the completed doses and major side effects of HD IL-2, and document the satisfaction level of clinicians. .Methods
A retrospective chart review of 40 health records of patients with melanoma or renal cell carcinoma who were treated with HD IL-2 was conducted to determine compliance to the SOS. Staff satisfaction with the SOS was surveyed. .Findings
The SOS was successfully implemented with a provider compliance rate of 90%. Cardiovascular side effects were the most common. Clinicians found the SOS very satisfactory or superior in guiding care and treatment of side effects.Full Text
Duke Authors
Cited Authors
- Portillas, R; Turner, B; Jeffers, A; Chen, L-L; Champagne, M
Published Date
- April 2017
Published In
Volume / Issue
- 21 / 2
Start / End Page
- E49 - E53
PubMed ID
- 28315535
Electronic International Standard Serial Number (EISSN)
- 1538-067X
International Standard Serial Number (ISSN)
- 1092-1095
Digital Object Identifier (DOI)
- 10.1188/17.cjon.e49-e53
Language
- eng