New insights into mononuclear phagocyte biology from the visual system.

Journal Article (Journal Article;Review)

Major advances in mononuclear phagocyte biology have been made but key questions pertinent to their roles in health and disease remain, including in the visual system. One problem concerns how dendritic cells can trigger immune responses from certain tightly regulated immune- privileged sites of the eye. Another, albeit separate, problem involves whether there are functional specializations for microglia versus monocytes in retinal neurodegeneration. In this Review, we examine novel insights in eye immune privilege and, separately, we discuss recent inroads concerning retinal degeneration. Both themes have been extensively studied in the visual system and show parallels with recent findings concerning mononuclear phagocytes in the central nervous system and in the periphery.

Full Text

Duke Authors

Cited Authors

  • Reyes, NJ; O'Koren, EG; Saban, DR

Published Date

  • May 2017

Published In

Volume / Issue

  • 17 / 5

Start / End Page

  • 322 - 332

PubMed ID

  • 28345586

Pubmed Central ID

  • PMC5810371

Electronic International Standard Serial Number (EISSN)

  • 1474-1741

Digital Object Identifier (DOI)

  • 10.1038/nri.2017.13

Language

  • eng

Conference Location

  • England